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Article

AlphaFold2 Can Predict Single-Mutation Effects.

Physical review letters - 24 Nov 2023

McBride John M, Polev Konstantin, Abdirasulov Amirbek, Reinharz Vladimir, Grzybowski Bartosz A, Tlusty Tsvi

Abstract excerpt

AlphaFold2 (AF) is a promising tool, but is it accurate enough to predict single mutation effects? Here, we report that the localized structural deformation between protein pairs differing by only 1-3 mutations-as measured by the effective strain-is correlated across 3901 experimental and AF-predicted structures. Furthermore, analysis of ∼11 000 proteins shows that the local structural change correlates with...

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Identifiers

PMID: 38072605
DOI: 10.1103/PhysRevLett.131.218401

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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