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Article

Using AlphaFold to predict the impact of single mutations on protein stability and function.

PloS one - 1 Jan 2023

Pak Marina A, Markhieva Karina A, Novikova Mariia S, Petrov Dmitry S, Vorobyev Ilya S, Maksimova Ekaterina S, Kondrashov Fyodor A, Ivankov Dmitry N

Abstract excerpt

AlphaFold changed the field of structural biology by achieving three-dimensional (3D) structure prediction from protein sequence at experimental quality. The astounding success even led to claims that the protein folding problem is "solved". However, protein folding problem is more than just structure prediction from sequence. Presently, it is unknown if the AlphaFold-triggered revolution could help to solve...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 36928239
DOI: 10.1371/journal.pone.0282689
PMCID: PMC10019719

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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