Multiple colorectal adenomas syndrome: The role of MUTYH mutation and the polyps' number in clinical management and colorectal cancer risk.

doi:10.1016/j.dld.2023.11.034

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Article

Multiple colorectal adenomas syndrome: The role of MUTYH mutation and the polyps' number in clinical management and colorectal cancer risk.

Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver - 1 Jun 2024

Negro Silvia, Bao Quoc Riccardo, Scarpa Marco, Scognamiglio Federico, Pucciarelli Salvatore, Remo Andrea, Agostini Marco, D'Angelo Edoardo, Mammi Isabella, Schiavi Francesca, Rossi Silvia, Zingone Fabiana, Ferrara Francesco, Fantin Alberto, Cristofori Chiara, Guido Ennio, Rizzotto Erik Rosa, Intini Rossana, Bergamo Francesca, Fassan Matteo, Salviati Leonardo, Urso Emanuele D L

Abstract excerpt

BACKGROUND & AIMS: Multiple colorectal adenomas (MCRAs) can result from APC (AFAP) or biallelic MUTYH (MAP) mutations, but most patients are wild type and referred to as non-APC/MUTYH polyposis (NAMP). We aim to examine the risk of colorectal cancer (CRC) and the role of endoscopy in managing patients with MCRAs, with a specific focus on clinical features and genotype. METHODS: Records of MRCAs between 2000 and...

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Identifiers

PMID: 38071180
DOI: 10.1016/j.dld.2023.11.034

Genes

MUTYH
APC

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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