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Article

Common colorectal cancer risk alleles contribute to the multiple colorectal adenoma phenotype, but do not influence colonic polyposis in FAP.

European journal of human genetics : EJHG - 1 Feb 2015

Cheng Timothy H T, Gorman Maggie, Martin Lynn, Barclay Ella, Casey Graham, Saunders Brian, Thomas Huw, Clark Sue, Tomlinson Ian

Abstract excerpt

The presence of multiple (5-100) colorectal adenomas suggests an inherited predisposition, but the genetic aetiology of this phenotype is undetermined if patients test negative for Mendelian polyposis syndromes such as familial adenomatous polyposis (FAP) and MUTYH-associated polyposis (MAP). We investigated whether 18 common colorectal cancer (CRC) predisposition single-nucleotide polymorphisms (SNPs) could help...

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Source

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Identifiers

PMID: 24801760
DOI: 10.1038/ejhg.2014.74
PMCID: PMC4140766

Genes

FAP
APC
MUTYH

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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