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Article

Improving the thermal stability and catalytic activity of ulvan lyase by the combination of FoldX and KnowVolution campaign.

International journal of biological macromolecules - 1 Feb 2024

Huang Ailan, Chen Zhengqi, Wu Xinming, Yan Wenxing, Lu Fuping, Liu Fufeng

Abstract excerpt

Thermal stability is one of the most important properties of ulvan lyases for their application in algae biomass degradation. The Knowledge gaining directed eVolution (KnowVolution) protein engineering strategy could be employed to improve thermostability of ulvan lyase with less screening effort. Herein, the unfolding free energies (ΔΔG) of the loop region were calculated using FoldX and four sites (D103, G104,...

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PMID: 38070809
DOI: 10.1016/j.ijbiomac.2023.128577

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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