Article
Plate-Based Assays for the Characterization of Mitochondrial and Cellular Phenotypes.
Methods in molecular biology (Clifton, N.J.) - 1 Jan 2024
Arnold Benjamin Henry, Sanislav Oana, Fisher Paul Robert, Annesley Sarah Jane
Abstract excerpt
The mitochondria are essential to eukaryotic life, acting as key drivers of energy generation while also being involved in the regulation of many cellular processes including apoptosis, cell proliferation, calcium homeostasis, and metabolism. Mitochondrial diseases which disrupt these processes lead to a diverse range of pathologies and lack consistency in symptom presentation. In disease, mitochondrial activity...
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