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Article

MaxCLK: discovery of cancer driver genes via maximal clique and information entropy of modules.

Bioinformatics (Oxford, England) - 1 Dec 2023

Liu Jian, Ma Fubin, Zhu Yongdi, Zhang Naiqian, Kong Lingming, Mi Jia, Cong Haiyan, Gao Rui, Wang Mingyi, Zhang Yusen

Abstract excerpt

MOTIVATION: Cancer is caused by the accumulation of somatic mutations in multiple pathways, in which driver mutations are typically of the properties of high coverage and high exclusivity in patients. Identifying cancer driver genes has a pivotal role in understanding the mechanisms of oncogenesis and treatment. RESULTS: Here, we introduced MaxCLK, an algorithm for identifying cancer driver genes, which was...

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Identifiers

PMID: 38065693
DOI: 10.1093/bioinformatics/btad737
PMCID: PMC10739565

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