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Article

New insights on mitochondrial heteroplasmy observed in ovarian diseases.

Journal of advanced research - 1 Nov 2024

Zhou Yong, Jin Yang, Wu Tianyu, Wang Yinfeng, Dong Yuanhang, Chen Pei, Hu Changchang, Pan Ningping, Ye Chaoshuang, Shen Li, Lin Mengyan, Fang Tao, Wu Ruijin

Abstract excerpt

BACKGROUND: The reportedly high mutation rate of mitochondrial DNA (mtDNA) may be attributed to the absence of histone protection and complete repair mechanisms. Mitochondrial heteroplasmy refers to the coexistence of wild-type and mutant mtDNA. Most healthy individuals carry a low point mutation load (<1 %) in their mtDNA, typically without any discernible phenotypic effects. However, as it exceeds a certain...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 38061426
DOI: 10.1016/j.jare.2023.11.033
PMCID: PMC11519015

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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