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Article

Exome and transcriptome analysis link calcium channel pathway aberrations to botulinum toxin A resistance in Hailey-Hailey disease.

The British journal of dermatology - 20 Jun 2025

Yuan Yongyong, Wang Hailun, Pan Meng, Zheng Jie, Zhang Li, Cao Han, Chen Xiaoying, Yang Yan

Abstract excerpt

BACKGROUND: The effectiveness of botulinum toxin A (BoNTA) in the treatment of Hailey-Hailey disease (HHD) has shown heterogeneity in recent studies. However, there is currently no research investigating the underlying mechanism behind the variability in patient response. OBJECTIVES: To identify potential biomarkers and elucidate the underlying mechanisms of the heterogeneity in efficacy of BoNTA treatment for...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 40317184
DOI: 10.1093/bjd/ljaf112

Genes

ATP2C1
ORAI1
ITPKC
NLRP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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