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Article

Sequential tumor molecular profiling identifies likely germline variants.

Genetics in medicine : official journal of the American College of Medical Genetics - 1 Mar 2024

Kraft Ira L, Basdag Hatice, Koppayi Ashwin, Rodgers Courtnee V, Saygin Caner, Haribabu Yogameenakshi, Wanjari Pankhuri, Niu Nifang, Das Soma, de Jong Jill L O, Segal Jeremy, Godley Lucy A

Abstract excerpt

PURPOSE: To identify likely germline DNA variants from sequential tumor profiling data from hematopoietic malignancies (HMs). METHODS: The coefficient of variance was calculated from variant allele frequency of next-generation sequencing assays. Variants' likelihood of being germline was ranked on a 1 to 5 scale. Outcomes were examined in patients with such variants. RESULTS: In a pilot set of 33 genes, 89% of...

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Identifiers

PMID: 38054407
DOI: 10.1016/j.gim.2023.101037
PMCID: PMC11401608

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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