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Article

Risks and Implications of Multiple Actionable Pathogenic Germline Variants Discovered by Panel-Based Cancer Predisposition Testing.

JCO precision oncology - 1 Oct 2025

Neumann Catherine, Dedousis Demitrios, Hall Michael J

Abstract excerpt

PURPOSE: Growing use of multigene panels (MGPs) is increasing the number of patients identified with multiple pathogenic germline variants (PGVs) in cancer predisposition genes. This study characterizes the landscape of patients with multiple PGVs and identifies clinical settings where multiple PGVs affect management. MATERIALS AND METHODS: This is a single-institution retrospective cohort analysis comprising...

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Identifiers

PMID: 41100774
DOI: 10.1200/PO-24-00951
PMCID: PMC12537039

Genes

BRCA1
BRCA2
MGP

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