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Article

Germline Analysis from Tumor-Germline Sequencing Dyads to Identify Clinically Actionable Secondary Findings.

Clinical cancer research : an official journal of the American Association for Cancer Research - 15 Aug 2016

Seifert Bryce A, O'Daniel Julianne M, Amin Krunal, Marchuk Daniel S, Patel Nirali M, Parker Joel S, Hoyle Alan P, Mose Lisle E, Marron Andrew, Hayward Michele C, Bizon Christopher, Wilhelmsen Kirk C, Evans James P, Earp H Shelton, Sharpless Norman E, Hayes D Neil, Berg Jonathan S

Abstract excerpt

PURPOSE: To evaluate germline variants in hereditary cancer susceptibility genes among unselected cancer patients undergoing tumor-germline sequencing. EXPERIMENTAL DESIGN: Germline sequence data from 439 individuals undergoing tumor-germline dyad sequencing through the LCCC1108/UNCseq™ (NCT01457196) study were analyzed for genetic variants in 36 hereditary cancer susceptibility genes. These variants were...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 27083775
DOI: 10.1158/1078-0432.CCR-16-0015
PMCID: PMC4987173

Genes

ATM
BRCA1
BRCA2
CHEK2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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