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Article

Distinct karyotypic and mutational landscape in trisomy AML.

British journal of haematology - 1 Mar 2024

Lam Stephen S Y, Tsui Sze P, Fung C Y, Saw Nicole Y, Javed Asif, Ip Alvin H W, Ma Edmond S K, Leung Anskar Y H

Abstract excerpt

Trisomy karyotype occurs in 5%-10% of AML. Its mutational landscape and prognostic significance are not well defined. A cohort of 156 trisomy AML patients was analysed, with reference to 615 cytogenetically normal (CN) AML patients. Trisomy AML showed distinct mutational landscape with more prevalent SMC1A, N/KRAS, ASXL1 and BCOR but fewer CEBPAbZIP and NPM1 mutations in patients ≤60, and fewer NPM1 mutations in...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 38054248
DOI: 10.1111/bjh.19249

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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