The RNA helicase DDX21 cooperates with ETS1 and FLI1 in cell cycle, immune evasion, and snoRNA processing in activated B-cell-like diffuse large B-cell lymphoma cells

Abstract excerpt

Diffuse large B-cell lymphoma (DLBCL) is a clinically and biologically heterogeneous disease, with the activated B-cell-like (ABC) subtype showing inferior outcomes. The ETS transcription factors ETS1 and FLI1 are recurrently gained and functionally relevant in DLBCL, yet their pathogenic role remains to be fully elucidated. Here, we describe their cooperation with the RNA regulatory machinery, demonstrating that...

Topics

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• Acute Myeloid Leukemia Research
• DEAD-box RNA Helicases
• Hematologic Neoplasms
• Leukemia, Myeloid, Acute
• Mutation
• Myelodysplastic Syndromes
• RNA Research and Splicing
• Ubiquitin and proteasome pathways

Identifiers and source

Literature Corpus work

1fa40a57-7632-5757-a1ed-36de905ce5f1

DOI

10.64898/2026.06.02.729583