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Article

The enrichment of Fanconi anemia/homologous recombination pathway aberrations in ATM/ATR-mutated NSCLC was accompanied by unique molecular features and poor prognosis.

Journal of translational medicine - 1 Dec 2023

Wei Wei, Shi Fangfang, Xu Yang, Jiao Yang, Zhang Ying, Ou Qiuxiang, Wu Xue, Yang Lingyi, Lai Jinhuo

Abstract excerpt

BACKGROUND: ATM and ATR are two critical factors to regulate DNA damage response (DDR), and their mutations were frequently observed in different types of cancer, including non-small cell lung cancer (NSCLC). Given that the majority of identified ATM/ATR mutations were variants of uncertain significance, the clinical/molecular features of pathogenic ATM/ATR aberrations have not been comprehensively investigated...

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Identifiers

PMID: 38041093
DOI: 10.1186/s12967-023-04634-1
PMCID: PMC10690992

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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