Clinicopathologic, Genomic, and Immunophenotypic Landscape of ATM Mutations in Non-Small Cell Lung Cancer.

doi:10.1158/1078-0432.CCR-22-3413

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Article

Clinicopathologic, Genomic, and Immunophenotypic Landscape of ATM Mutations in Non-Small Cell Lung Cancer.

Clinical cancer research : an official journal of the American Association for Cancer Research - 5 Jul 2023

Ricciuti Biagio, Elkrief Arielle, Alessi Joao, Wang Xinan, Li Yvonne, Gupta Hersh, Muldoon Daniel M, Bertram Arrien A, Pecci Federica, Lamberti Giuseppe, Di Federico Alessandro, Barrichello Adriana, Vaz Victor R, Gandhi Malini, Lee Elinton, Shapiro Geoffrey I, Park Hyesun, Nishino Mizuki, Lindsay James, Felt Kristen D, Sharma Bijaya, Cherniack Andrew D, Rodig Scott, Gomez Daniel R, Shaverdian Narek, Rakaee Mehrdad, Bandlamudi Chaitanya, Ladanyi Marc, Janne Pasi A, Schoenfeld Adam J, Sholl Lynette M, Awad Mark M, Cheng Michael L

Abstract excerpt

PURPOSE: ATM is the most commonly mutated DNA damage and repair gene in non-small cell lung cancer (NSCLC); however, limited characterization has been pursued. EXPERIMENTAL DESIGN: Clinicopathologic, genomic, and treatment data were collected for 5,172 patients with NSCLC tumors which underwent genomic profiling. ATM IHC was performed on 182 NSCLCs with ATM mutations. Multiplexed immunofluorescence was performed...

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PMID: 37097610
DOI: 10.1158/1078-0432.CCR-22-3413
PMCID: PMC11031845

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