ATM Mutations Associate with Distinct Co-Mutational Patterns and Therapeutic Vulnerabilities in NSCLC.

doi:10.1158/1078-0432.CCR-23-1122

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Article

ATM Mutations Associate with Distinct Co-Mutational Patterns and Therapeutic Vulnerabilities in NSCLC.

Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Dec 2023

Vokes Natalie I, Galan Cobo Ana, Fernandez-Chas Margarita, Molkentine David, Treviño Santiago, Druker Vitaly, Qian Yu, Patel Sonia, Schmidt Stephanie, Hong Lingzhi, Lewis Jeff, Rinsurongkawong Waree, Rinsurongkawong Vadeerat, Lee J Jack, Negrao Marcelo V, Gibbons Don L, Vaporciyan Ara, Le Xiuning, Wu Jia, Zhang Jianjun, Rigney Una, Iyer Sonia, Dean Emma, Heymach John V

Abstract excerpt

PURPOSE: Ataxia-telangiectasia mutated (ATM) is the most frequently mutated DNA damage repair gene in non-small cell lung cancer (NSCLC). However, the molecular correlates of ATM mutations and their clinical implications have not been fully elucidated. EXPERIMENTAL DESIGN: Clinicopathologic and genomic data from 26,587 patients with NSCLC from MD Anderson, public databases, and a de-identified nationwide...

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PMID: 37733794
DOI: 10.1158/1078-0432.CCR-23-1122
PMCID: PMC10690143

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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