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Article

Clinical significance of DNA damage response mutations in stage I and stage IIIa NSCLC.

Thoracic cancer - 1 Nov 2023

Zhang Haoran, Zhang Dongming, Liu Jia, Shi Yuequan, Liu Xiaoyan, Chen Minjiang, Zhong Wei, Zhao Jing, Xu Yan, Wang Mengzhao

Abstract excerpt

BACKGROUND: DNA damage response (DDR) pathways are essential to sustain genomic stability and play a critical role in cancer development and progression. Here, we investigated the profile of DDR gene mutations in early-stage non-small cell lung cancer (NSCLC) and their prognostic values. METHODS: We first examined 74 DDR genes involved in seven DDR pathways and then focused on six specific genes: ATM, BRCA1,...

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Identifiers

PMID: 37704455
DOI: 10.1111/1759-7714.15109
PMCID: PMC10643798

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