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Article

High-frequency variants in PKA signaling-related genes within a large pediatric cohort with obesity or metabolic abnormalities.

Frontiers in endocrinology - 1 Jan 2023

Bloyd Michelle, Sinaii Ninet, Faucz Fabio Rueda, Iben James, Coon Steven L, Caprio Sonia, Santoro Nicola, Stratakis Constantine A, London Edra

Abstract excerpt

Introduction: Pediatric obesity has steadily increased in recent decades. Large-scale genome-wide association studies (GWAS) conducted primarily in Eurocentric adult populations have identified approximately 100 loci that predispose to obesity and type II diabetes. GWAS in children and individuals of non-European descent, both disproportionately affected by obesity, are fewer. Rare syndromic and monogenic...

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Identifiers

PMID: 38027204
DOI: 10.3389/fendo.2023.1272939
PMCID: PMC10679389

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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