Article
From a mutation to a drug
Postepy biochemii - 30 Sept 2023
Wnuk Jan, Wilanowski Tomasz
Abstract excerpt
Malignant melanoma is a dangerous skin cancer, accounting for the majority of skin cancer-related deaths. Many patients with this cancer have the V600E mutation in the BRAF gene. This mutation causes constitutive activation of the MAPK/ERK signaling pathway, significantly contributing to the process of carcinogenesis. We discuss the drug design process on the example of a specific BRAF V600E inhibitor,...
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