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Article

Insights into the structure-activity relationship of pyrimidine-sulfonamide analogues for targeting BRAF V600E protein.

Biophysical chemistry - 1 Apr 2024

Srisongkram Tarapong, Tookkane Dheerapat

Abstract excerpt

B-rapidly accelerated fibrosarcoma (BRAF) V600E plays a crucial role in the progression of cutaneous melanoma. Core structures of BRAF V600E inhibitors are based on pyrimidine-sulfonamide scaffolds. Exploring the QSAR of these structures can improve our understanding of BRAF V600E inhibitor drug design. This study utilized machine learning-based QSAR to elucidate chemical substructures of pyrimidine-sulfonamide...

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Source

Identifiers

PMID: 38241826
DOI: 10.1016/j.bpc.2024.107179

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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