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Article

Molecular Modeling Unveils the Effective Interaction of B-RAF Inhibitors with Rare B-RAF Insertion Variants.

International journal of molecular sciences - 31 Jul 2023

Scaini Maria Chiara, Piccin Luisa, Bassani Davide, Scapinello Antonio, Pellegrini Stefania, Poggiana Cristina, Catoni Cristina, Tonello Debora, Pigozzo Jacopo, Dall'Olmo Luigi, Rosato Antonio, Moro Stefano, Chiarion-Sileni Vanna, Menin Chiara

Abstract excerpt

The Food and Drug Administration (FDA) has approved MAPK inhibitors as a treatment for melanoma patients carrying a mutation in codon V600 of the BRAF gene exclusively. However, BRAF mutations outside the V600 codon may occur in a small percentage of melanomas. Although these rare variants may cause B-RAF activation, their predictive response to B-RAF inhibitor treatments is still poorly understood. We exploited...

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PMID: 37569660
DOI: 10.3390/ijms241512285
PMCID: PMC10418914

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