Article
MiRNA therapeutics based on logic circuits of biological pathways.
BMC bioinformatics - 22 Nov 2019
Boscaino Valeria, Fiannaca Antonino, La Paglia Laura, La Rosa Massimo, Rizzo Riccardo, Urso Alfonso
Abstract excerpt
BACKGROUND: In silico experiments, with the aid of computer simulation, speed up the process of in vitro or in vivo experiments. Cancer therapy design is often based on signalling pathway. MicroRNAs (miRNA) are small non-coding RNA molecules. In several kinds of diseases, including cancer, hepatitis and cardiovascular diseases, they are often deregulated, acting as oncogenes or tumor suppressors. miRNA...
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