Article
Non-synonymous Single Nucleotide Polymorphisms in Human ACE2 Gene May Affect the Infectivity of SARS-CoV-2 Omicron Subvariants.
Current pharmaceutical design - 1 Jan 2023
Samanta Arijit, Ahamed Ashif, Alam Syed Sahajada Mahafujul, Ali Safdar, Shahnawaz Khan Mohd, Al-Amri Abdulaziz M, Tabrez Shams, Hoque Mehboob
Abstract excerpt
BACKGROUND: The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes the coronavirus disease 2019 (COVID-19), which first appeared in December 2019. Angiotensin I converting enzyme 2 (ACE2) receptor, present on the host cells, interacts with the receptor binding domain (RBD) of spike (S) protein of SARS-CoV-2 and facilitates the viral entry into host cells. METHODS: Non-synonymous single nucleotide...
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