Article
A Novel LRP6 Mutation Highlights the Role of Wnt Signaling in Tooth Agenesis.
Genesis (New York, N.Y. : 2000) - 1 Dec 2025
Wang Xinyuan, Wu Linrui, Xiong Runji, Wang Yaxin, Zhao Yuanyuan, Jin Runming, Zhao Jiajia
Abstract excerpt
Non-syndromic tooth agenesis (TA) is a rare developmental disorder that impairs oral function, systemic health, psychological well-being, and quality of life. The Wnt signaling pathway plays a central role in TA pathogenesis, and emerging evidence implicates that the low-density lipoprotein receptor-related protein 6 (LRP6) is involved in autosomal-dominant inheritance of TA. In this study, whole-exome sequencing...
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