Article
Mutations in LRP6 highlight the role of WNT signaling in oral exostoses and dental anomalies.
Archives of oral biology - 1 Oct 2022
Kantaputra Piranit, Jatooratthawichot Peeranat, Chintakanon Kanoknart, Intachai Worrachet, Pradermdutsadeeporn Prapat, Adisornkanj Ploy, Tongsima Sissades, Ngamphiw Chumpol, Olsen Bjorn, Tucker Abigail S, Ketudat Cairns James R
Abstract excerpt
OBJECTIVE: The objective of this study was to investigate molecular etiologies of oral exostoses and dental anomalies in 14 patients from eight families. METHODS: Oral and radiographic examinations were performed on every patient. Whole exome and Sanger sequencing were performed on DNA of the patients, the unaffected parents and unaffected siblings. LRP6 mutant proteins were modeled and analyzed. RESULTS: Five...
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