Article
Genetic Variants in KCTD1 Are Associated with Isolated Dental Anomalies.
International journal of molecular sciences - 9 May 2024
Ruangchan Cholaporn, Ngamphiw Chumpol, Krasaesin Annop, Intarak Narin, Tongsima Sissades, Kaewgahya Massupa, Kawasaki Katsushige, Mahawong Phitsanu, Paripurana Kullaya, Sookawat Bussaneeya, Jatooratthawichot Peeranat, Cox Timothy C, Ohazama Atsushi, Ketudat Cairns James R, Porntaveetus Thantrira, Kantaputra Piranit
Abstract excerpt
KCTD1 plays crucial roles in regulating both the SHH and WNT/β-catenin signaling pathways, which are essential for tooth development. The objective of this study was to investigate if genetic variants in KCTD1 might also be associated with isolated dental anomalies. We clinically and radiographically investigated 362 patients affected with isolated dental anomalies. Whole exome sequencing identified two unrelated...
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