Genetic Variants in DVL3 are Associated With Root Maldevelopment, Tooth Agenesis, Mesiodens, and Oral Exostoses.

doi:10.1016/j.identj.2025.104019

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Article

Genetic Variants in DVL3 are Associated With Root Maldevelopment, Tooth Agenesis, Mesiodens, and Oral Exostoses.

International dental journal - 1 Feb 2026

Kantaputra Piranit, Bunpiem Narumon, Guven Yeliz, Tripuwabhrut Kanich, Kalayci Tugba, Imren Ebru, Sengtae Nuttaporn, Pianmee Chawalid, Pruksametanan Apitchaya, Tongsima Sissades, Ngamphiw Chumpol, Kawasaki Katsushige, Ohazama Atsushi, Cairns James R Ketudat

Abstract excerpt

DVL3 regulates tooth initiation, root formation, and craniofacial patterning through canonical and non-canonical WNT signalling. The objective of this study was to investigate the dental and craniofacial phenotypes associated with rare or novel DVL3 variants in Thai and Turkish patients. It aimed to broaden the understanding of the clinical spectrum of DVL3-related conditions, particularly their role in...

Read the complete abstract on PubMed

Topics

Humans
Dishevelled Proteins
Male
Female
Tooth Root

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Child

Adolescent

Tooth Abnormalities

Turkey

Anodontia

Phenotype

Genetic Variation

Adult

Odontogenesis

Child, Preschool

Source

Open in PubMed Open full text

Identifiers

PMID: 41265171
DOI: 10.1016/j.identj.2025.104019
PMCID: PMC12671360

Genes

DVL3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 19 Oct 2026.

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