Article
Novel Dental Anomaly-associated Mutations in WNT10A Protein Binding Sites.
International dental journal - 1 Feb 2023
Kantaputra Piranit, Jatooratthawichot Peeranat, Tantachamroon Oranuch, Nanekrungsan Kamonporn, Intachai Worrachet, Olsen Bjorn, Tongsima Sissades, Ngamphiw Chumpol, Cairns James R Ketudat
Abstract excerpt
OBJECTIVE: WNT/β-catenin signaling is initiated by binding of a WNT protein to a Frizzled (FZD) receptor and a co-receptor, low-density lipoprotein (LDL) receptor-related protein 5 or 6 (LRP5/6). The objective of this study was to find the genetic variants responsible for dental anomalies found in 4 families. METHODS: Clinical and radiographic examination and whole exome sequencing were performed on 5 patients...
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