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COPI vesicle formation and N-myristoylation are targetable vulnerabilities of senescent cells

27 Nov 2023

Abstract excerpt

Drugs that selectively kill senescent cells (senolytics) improve the outcomes of cancer, fibrosis and age-related diseases. Despite their potential, our knowledge of the molecular pathways that affect the survival of senescent cells is limited. To discover senolytic targets, we performed RNAi screens and identified coatomer complex I (COPI) vesicle formation as a liability of senescent cells. Genetic or...

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PMID: 38012402
DOI: 10.1038/s41556-023-01287-6

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