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Abortive Autophagy Induces Endoplasmic Reticulum Stress and Cell Death in Cancer Cells

26 Jun 2012

Abstract excerpt

Autophagic cell death or abortive autophagy has been proposed to eliminate damaged as well as cancer cells, but there remains a critical gap in our knowledge in how this process is regulated. The goal of this study was to identify modulators of the autophagic cell death pathway and elucidate their effects on cellular signaling and function. The result of our siRNA library screenings show that an intact coatomer...

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PMID: 22745748
DOI: 10.1371/journal.pone.0039400

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