Article
Sickle cell trait is not associated with endemic Burkitt lymphoma: an ethnicity and malaria endemicity-matched case-control study suggests factors controlling EBV may serve as a predictive biomarker for this pediatric cancer.
International journal of cancer - 1 Feb 2014
Mulama David H, Bailey Jeffrey A, Foley Joslyn, Chelimo Kiprotich, Ouma Collins, Jura Walter G Z O, Otieno Juliana, Vulule John, Moormann Ann M
Abstract excerpt
Endemic Burkitt lymphoma (eBL) is associated with Epstein-Barr virus (EBV) and Plasmodium falciparum coinfections. Malaria appears to dysregulate immunity that would otherwise control EBV, thereby contributing to eBL etiology. Juxtaposed to human genetic variants associated with protection from malaria, it has been hypothesized that such variants could decrease eBL susceptibility, historically referred to as "the...
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