Upregulated expression of miR-4443 and miR-4488 in drug resistant melanomas promotes migratory and invasive phenotypes through downregulation of intermediate filament nestin.

doi:10.1186/s13046-023-02878-9

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Article

Upregulated expression of miR-4443 and miR-4488 in drug resistant melanomas promotes migratory and invasive phenotypes through downregulation of intermediate filament nestin.

Journal of experimental & clinical cancer research : CR - 27 Nov 2023

Castaldo Vittorio, Minopoli Michele, Di Modugno Francesca, Sacconi Andrea, Liguoro Domenico, Frigerio Rachele, Ortolano Arianna, Di Martile Marta, Gesualdi Luisa, Madonna Gabriele, Capone Mariaelena, Cirombella Roberto, Catizone Angiolina, Del Bufalo Donatella, Vecchione Andrea, Carriero Maria Vincenza, Ascierto Paolo Antonio, Mancini Rita, Fattore Luigi, Ciliberto Gennaro

Abstract excerpt

BACKGROUND: BRAF-mutant melanoma patients benefit from the combinatorial treatments with BRAF and MEK inhibitors. However, acquired drug resistance strongly limits the efficacy of these targeted therapies in time. Recently, many findings have underscored the involvement of microRNAs as main drivers of drug resistance. In this context, we previously identified a subset of oncomiRs strongly up-regulated in...

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PMID: 38008717
DOI: 10.1186/s13046-023-02878-9
PMCID: PMC10680267

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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