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Article

YBX1 Regulates Satellite II RNA Loading into Small Extracellular Vesicles and Promotes the Senescent Phenotype.

International journal of molecular sciences - 16 Nov 2023

Chiba Masatomo, Miyata Kenichi, Okawa Hikaru, Tanaka Yoko, Ueda Koji, Seimiya Hiroyuki, Takahashi Akiko

Abstract excerpt

Senescent cells secrete inflammatory proteins and small extracellular vesicles (sEVs), collectively termed senescence-associated secretory phenotype (SASP), and promote age-related diseases. Epigenetic alteration in senescent cells induces the expression of satellite II (SATII) RNA, non-coding RNA transcribed from pericentromeric repetitive sequences in the genome, leading to the expression of inflammatory SASP...

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Identifiers

PMID: 38003589
DOI: 10.3390/ijms242216399
PMCID: PMC10671301

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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