Article
Heritable genomic diversity in breast cancer driver genes and associations with risk in a Chilean population.
Biological research - 31 May 2022
Morales-Pison Sebastian, Gonzalez-Hormazabal Patricio, Tapia Julio C, Salas-Burgos Alexis, Ampuero Sandra, Gómez Fernando, Waugh Enrique, Reyes José Miguel, Jara Lilian
Abstract excerpt
BACKGROUND: Driver mutations are the genetic components responsible for tumor initiation and progression. These variants, which may be inherited, influence cancer risk and therefore underlie many familial cancers. The present study examines the potential association between SNPs in driver genes SF3B1 (rs4685), TBX3 (rs12366395, rs8853, and rs1061651) and MAP3K1 (rs72758040) and BC in BRCA1/2-negative Chilean...