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Article

Escitalopram-induced QTc prolongation and its relationship with KCNQ1, KCNE1, and KCNH2 gene polymorphisms.

Journal of affective disorders - 15 Feb 2024

Chen Zimu, Xu Zhi, Gao Chenjie, Chen Lei, Tan Tingting, Jiang Wenhao, Chen Bingwei, Yuan Yonggui, Zhang Zhijun

Abstract excerpt

BACKGROUND: Escitalopram can cause prolongation of the QT interval on the electrocardiogram (ECG). However, only some patients get pathological QTc prolongation in clinic. We investigated the influence of KCNQ1, KCNE1, and KCNH2 gene polymorphisms along with clinical factors on escitalopram-induced QTc prolongation. METHODS: A total of 713 patients prescribed escitalopram were identified and had at least one ECG...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Polymorphism, Single Nucleotide

Share to Potassium Channels, Voltage-Gated

Source

Identifiers

PMID: 38000475
DOI: 10.1016/j.jad.2023.11.084

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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