Article
An atypical GABARAP binding module drives the pro-autophagic potential of the AML-associated NPM1c variant.
Cell reports - 26 Dec 2023
Mende Hannah, Khatri Anshu, Lange Carolin, Poveda-Cuevas Sergio Alejandro, Tascher Georg, Covarrubias-Pinto Adriana, Löhr Frank, Koschade Sebastian E, Dikic Ivan, Münch Christian, Bremm Anja, Brunetti Lorenzo, Brandts Christian H, Uckelmann Hannah, Dötsch Volker, Rogov Vladimir V, Bhaskara Ramachandra M, Müller Stefan
Abstract excerpt
The nucleolar scaffold protein NPM1 is a multifunctional regulator of cellular homeostasis, genome integrity, and stress response. NPM1 mutations, known as NPM1c variants promoting its aberrant cytoplasmic localization, are the most frequent genetic alterations in acute myeloid leukemia (AML). A hallmark of AML cells is their dependency on elevated autophagic flux. Here, we show that NPM1 and NPM1c induce the...
Topics
- Humans
- Nuclear Proteins
- Leukemia, Myeloid, Acute
- Autophagy
- Mutation
- Lysosomes
- Microtubule-Associated Proteins
- Apoptosis Regulatory Proteins