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Article

Atorvastatin Promotes Pro/anti-inflammatory Phenotypic Transformation of Microglia via Wnt/β-catenin Pathway in Hypoxic-Ischemic Neonatal Rats.

Molecular neurobiology - 1 Jun 2024

Yu Luting, Huang Lingyi, Zhao Yuanyuan, Liu Shixi, Zhou Ruixi, Yue Yan, Sun Hao, Su Xiaojuan, Liu Qian, Li Shiping, Ying Junjie, Zhao Fengyan, Qu Yi

Abstract excerpt

Inflammatory reaction plays a key role in the pathogenesis of hypoxic-ischemic encephalopathy (HIE) in neonates. Microglia are resident innate immune cells in the central nervous system and are profoundly involved in neuroinflammation. Studies have revealed that atorvastatin exerts a neuroprotective effect by regulating neuroinflammation in adult animal models of brain stroke and traumatic brain injury, but its...

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Identifiers

PMID: 37996729
DOI: 10.1007/s12035-023-03777-y
PMCID: PMC11087325

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