Article
Evaluation of circulating plasma proteins in breast cancer using Mendelian randomisation.
Nature communications - 24 Nov 2023
Mälarstig Anders, Grassmann Felix, Dahl Leo, Dimitriou Marios, McLeod Dianna, Gabrielson Marike, Smith-Byrne Karl, Thomas Cecilia E, Huang Tzu-Hsuan, Forsberg Simon K G, Eriksson Per, Ulfstedt Mikael, Johansson Mattias, Sokolov Aleksandr V, Schiöth Helgi B, Hall Per, Schwenk Jochen M, Czene Kamila, Hedman Åsa K
Abstract excerpt
Biomarkers for early detection of breast cancer may complement population screening approaches to enable earlier and more precise treatment. The blood proteome is an important source for biomarker discovery but so far, few proteins have been identified with breast cancer risk. Here, we measure 2929 unique proteins in plasma from 598 women selected from the Karolinska Mammography Project to explore the association...
Topics
- Humans
- Female
- Breast Neoplasms
- Biomarkers
- Mammography
- Phenotype
- Blood Proteins
- Mendelian Randomization Analysis
- Genome-Wide Association Study