Identifying new biomarkers and potential therapeutic targets for breast cancer through the integration of human plasma proteomics: a Mendelian randomization study and colocalization analysis.

Abstract excerpt

Background: The proteome is a crucial reservoir of targets for cancer treatment. While some targeted therapies have been developed, there are still significant challenges in early diagnosis and treatment, highlighting the need to identify new biomarkers and therapeutic targets for breast cancer. Therefore, we conducted a comprehensive proteome-wide Mendelian randomization (MR) study to identify novel biomarkers...

Topics

• Humans
• Breast Neoplasms
• Female
• Mendelian Randomization Analysis
• Biomarkers, Tumor
• Proteomics
• Quantitative Trait Loci
• Proteome
• Protein Interaction Maps
• Genome-Wide Association Study