Article
A tortoise-hare pattern seen in adapting structured and unstructured populations suggests a rugged fitness landscape in bacteria.
Proceedings of the National Academy of Sciences of the United States of America - 16 Jun 2015
Nahum Joshua R, Godfrey-Smith Peter, Harding Brittany N, Marcus Joseph H, Carlson-Stevermer Jared, Kerr Benjamin
Abstract excerpt
In the context of Wright's adaptive landscape, genetic epistasis can yield a multipeaked or "rugged" topography. In an unstructured population, a lineage with selective access to multiple peaks is expected to fix rapidly on one, which may not be the highest peak. In a spatially structured population, on the other hand, beneficial mutations take longer to spread. This slowdown allows distant parts of the...
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