Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The clinical relevance of WDFY4 in autoimmune diseases in diverse ancestral populations.

Rheumatology (Oxford, England) - 1 Dec 2024

Lyu Xia, Lamb Janine A, Chinoy Hector

Abstract excerpt

WD repeat- and FYVE domain-containing protein 4 (WDFY4), coded by a gene on 10q11.23, is a member of the BEACH (Beige and Chediak-Higashi) domain-containing family. Genome-wide association studies identified WDFY4 variants as a risk factor for SLE in Asian and European populations. WDFY4 variants are also associated with RA and primary biliary cholangitis, in different ancestry populations. The WDFY4 protein...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Asian People
Share to Autoimmune Diseases
Share to Clinical Relevance

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Eosinophilic Disorders and Syndromes

Share to Genetic Predisposition to Disease

Share to Genome-Wide Association Study

Share to Immunodeficiency and Autoimmune Disorders

Share to Inflammatory Myopathies and Dermatomyositis

Source

Open in PubMed Open full text

Identifiers

PMID: 38507703
DOI: 10.1093/rheumatology/keae183
PMCID: PMC11637422

Genes

WDFY4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The clinical relevance of WDFY4 in autoimmune diseases in diverse ancestral populations.PMID 38507703Read ↗

Splicing variant of WDFY4 augments MDA5 signalling and the risk of clinically amyopathic dermatomyositis.Semantic proximity Read ↗

Insights into pathogenesis and clinical implications in myositis-associated interstitial lung diseases.Semantic proximity Read ↗

WDFY4 polymorphisms in Chinese patients with anti-MDA5 dermatomyositis is associated with rapid progressive interstitial lung diseaseSemantic proximity Read ↗

Genome-wide association study in Asian populations identifies variants in ETS1 and WDFY4 associated with systemic lupus erythematosus.Semantic proximity Read ↗

WDFY4 Is Involved in Symptoms of Systemic Lupus Erythematosus by Modulating B Cell Fate via Noncanonical AutophagySemantic proximity Read ↗

Multi-omics pan-cancer analysis reveals an immunological role and prognostic potential of WDR76Semantic proximity Read ↗

Integrative analysis reveals the role of THBS1 in IgG4-related diseaseSemantic proximity Read ↗

Rare genetic variants provide a mechanistic basis for immune imbalance in IgG4-related disease.Semantic proximity Read ↗

IKZF1 and UBR4 gene variants drive autoimmunity and Th2 polarization in IgG4-related diseaseSemantic proximity Read ↗

Comprehensive analysis reveals potential molecular targets in Juvenile DermatomyositisSemantic proximity Read ↗

Genome-wide association studies reveal new insights into the genetic basis of IgG4-related disease in the Chinese Han population.Semantic proximity Read ↗

Analysis of the Potential Link Between Dermatomyositis and CancerSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.