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Article

Sex differences in protein expression in the mouse brain and their perturbations in a model of Down syndrome

9 Nov 2015

Abstract excerpt

BACKGROUND: While many sex differences in structure and function of the mammalian brain have been described, the molecular correlates of these differences are not broadly known. Also unknown is how sex differences at the protein level are perturbed by mutations that lead to intellectual disability (ID). Down syndrome (DS) is the most common genetic cause of ID and is due to trisomy of human chromosome 21 (Hsa21)...

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PMID: 26557979
DOI: 10.1186/s13293-015-0043-9

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