Single‐cell RNA sequencing of human prostate basal epithelial cells reveals zone‐specific cellular populations and gene expression signatures

Abstract excerpt

Despite evidence of genetic signatures in normal tissue correlating with disease risk, prospectively identifying genetic drivers and cell types that underlie subsequent pathologies has historically been challenging. The human prostate is an ideal model to investigate this phenomenon because it is anatomically segregated into three glandular zones (central, peripheral, and transition) that develop differential...

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