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Article

A new fluorescent probe for the visualization of progerin.

Bioorganic chemistry - 1 Jan 2024

Macicior Jon, Fernández Daniel, Ortega-Gutiérrez Silvia

Abstract excerpt

Hutchinson-Gilford progeria syndrome (HGPS) or progeria is a rare genetic disease that causes premature aging, leading to a drastic reduction in the life expectancy of patients. Progeria is mainly caused by the intracellular accumulation of a defective protein called progerin, generated from a mutation in the LMNA gene. Currently, there is only one approved drug for the treatment of progeria, which has limited...

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PMID: 37979321
DOI: 10.1016/j.bioorg.2023.106967

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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