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Article

Small-Molecule Therapeutic Perspectives for the Treatment of Progeria.

International journal of molecular sciences - 3 Jul 2021

Macicior Jon, Marcos-Ramiro Beatriz, Ortega-Gutiérrez Silvia

Abstract excerpt

Hutchinson-Gilford progeria syndrome (HGPS), or progeria, is an extremely rare disorder that belongs to the class of laminopathies, diseases characterized by alterations in the genes that encode for the lamin proteins or for their associated interacting proteins. In particular, progeria is caused by a point mutation in the gene that codifies for the lamin A gene. This mutation ultimately leads to the biosynthesis...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 34281245
DOI: 10.3390/ijms22137190
PMCID: PMC8267806

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