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Article

An integrative and comparative study of pan-cancer transcriptomes reveals distinct cancer common and specific signatures.

Scientific reports - 16 Sept 2016

Cao Zhen, Zhang Shihua

Abstract excerpt

To investigate the commonalities and specificities across tumor lineages, we perform a systematic pan-cancer transcriptomic study across 6744 specimens. We find six pan-cancer subnetwork signatures which relate to cell cycle, immune response, Sp1 regulation, collagen, muscle system and angiogenesis. Moreover, four pan-cancer subnetwork signatures demonstrate strong prognostic potential. We also characterize 16...

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Identifiers

PMID: 27633916
DOI: 10.1038/srep33398
PMCID: PMC5025752

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