Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Targeting the conserved coronavirus octamer motif GGAAGAGC is a strategy for the development of coronavirus vaccine.

Virology journal - 15 Nov 2023

Lin Ching-Hung, Hsieh Feng-Cheng, Chang Yu-Chia, Yang Cheng-Yao, Hsu Hsuan-Wei, Yang Chun-Chun, Tam Hon-Man-Herman, Wu Hung-Yi

Abstract excerpt

BACKGROUND: Coronaviruses are pathogens of humans and animals that cause widespread and costly diseases. The development of effective strategies to combat the threat of coronaviruses is therefore a top priority. The conserved coronavirus octamer motif 5'GGAAGAGC3' exists in the 3' untranslated region of all identified coronaviruses. In the current study, we aimed to examine whether targeting the coronavirus...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cells, Cultured
Share to COVID-19 Vaccines

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Interferons

Share to Murine hepatitis virus

Share to Mutation

Share to SARS-CoV-2

Source

Open in PubMed Open full text

Identifiers

PMID: 37968733
DOI: 10.1186/s12985-023-02231-8
PMCID: PMC10652495

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Targeting the conserved coronavirus octamer motif GGAAGAGC is a strategy for the development of coronavirus vaccine.PMID 37968733Read ↗

A Mouse Upper Respiratory Tract Coronavirus Infection Model with OC43 Defines Toll-Like Receptor 2/6 Mediated Innate Immune ProtectionSemantic proximity Read ↗

Unveiling the biology of defective viral genomes in vitro and in vivo: implications for gene expression and pathogenesis of coronavirusSemantic proximity Read ↗

Live attenuated coronavirus vaccines deficient in N7-Methyltransferase activity induce both humoral and cellular immune responses in mice.Semantic proximity Read ↗

Manipulation of the infectious bronchitis coronavirus genome for vaccine development and analysis of the accessory proteinsSemantic proximity Read ↗

A Hypervariable Region within the 3′ <i>cis</i> -Acting Element of the Murine Coronavirus Genome Is Nonessential for RNA Synthesis but Affects PathogenesisSemantic proximity Read ↗

MERS-CoV Accessory ORFs Play Key Role for Infection and Pathogenesis.Semantic proximity Read ↗

Effective interferon (IFN)-λ treatment regimen to control lethal MERS-CoV infection in miceSemantic proximity Read ↗

The La Crosse virus Gc head domain is a major determinant of infection and pathogenesis.Semantic proximity Read ↗

MERS-CoV ORF4b is a virulence factor involved in the inflammatory pathology induced in the lungs of miceSemantic proximity Read ↗

Vesicular stomatitis virus chimeras expressing the Oropouche virus glycoproteins elicit protective immune responses in miceSemantic proximity Read ↗

Recombinant Mouse Hepatitis Virus Strain A59 from Cloned, Full-Length cDNA Replicates to High Titers In Vitro and Is Fully Pathogenic In VivoSemantic proximity Read ↗

C1qa deficiency in mice increases susceptibility to mouse hepatitis virus A59 infection.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.