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MERS-CoV ORF4b is a virulence factor involved in the inflammatory pathology induced in the lungs of mice

21 Sept 2022

Abstract excerpt

No vaccines or specific antiviral drugs are authorized against Middle East respiratory syndrome coronavirus (MERS-CoV) despite its high mortality rate and prevalence in dromedary camels. Since 2012, MERS-CoV has been causing sporadic zoonotic infections in humans, which poses a risk of genetic evolution to become a pandemic virus. MERS-CoV genome encodes five accessory proteins, 3, 4a, 4b, 5 and 8b for which...

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PMID: 36129908
DOI: 10.1371/journal.ppat.1010834

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