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Article

Distinct transduction difference between adeno-associated virus type 1 and type 6 vectors in human polarized airway epithelia.

Gene therapy - 1 Mar 2013

Yan Z, Lei-Butters D C M, Keiser N W, Engelhardt J F

Abstract excerpt

Of the many biologically isolated adeno-associated virus (AAV) serotypes, AAV1 and AAV6 share the highest degree of sequence homology, with only six different capsid residues. We compared the transduction efficiencies of rAAV1 and rAAV6 in primary polarized human airway epithelia and found significant differences in their abilities to transduce epithelia from the apical and basolateral membranes. rAAV1...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 22695783
DOI: 10.1038/gt.2012.46
PMCID: PMC3443503

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